A database of duplicated genes in fish
Curated by Yves Van de Peer, John S. Taylor, Jayabalan Joseph, and Axel Meyer
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| Comparative genomics
has shown that ray finned fish (Actinopterygii) contain more copies of
many genes than other vertebrates. A large number of these additional genes
appear to have been produced during a genome duplication event that occurred
early during the evolution of Actinopterygii (i.e., before the teleost
radiation). In addition to this ancient genome duplication event, many
lineages within Actinopterygii have experienced more recent genome duplications.
Here we introduce a curated database named Wanda that lists groups of orthologous
genes with one copy from man, mouse and chicken, one or two from tetraploid
Xenopus, and two or more ancient copies (i.e., paralogs) from ray finned
fish. The database also contains the sequence alignments and phylogenetic
trees that were necessary for determining the correct orthologous and paralogous
relationships among genes. Where available, map positions and functional
data are also reported. The Wanda database should be of particular use
to evolutionary and developmental biologists who are interested in the
evolutionary and functional divergence of genes after duplication.
Note: Wanda is still under construction. By the end of January, we hope to have added another 20 genes. Stay tuned! |
